“A lot of the previous findings kept bringing us back to PGE2 and its receptors. So we investigated whether it's possible to block the EP1 receptor so PGE2 couldn't trigger toxic effects.”
“ONO-8713 significantly reduced brain damage in our mouse models following activation of a nervous-system response known to cause brain damage in humans during stroke.”
“Our results strongly suggest that given the side effects associated with COX inhibitors, we should focus our efforts on developing drugs that block the EP1 receptor instead of inhibiting COX-2 activity.”
